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TPA (PMA)

 

Active Product:

Appearance: film or powder

Brand name(s):
Chemical Name: 12-O-Tetradecanoylphorbol 13-acetate, PMA, TPA, 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate
Molecular Weight: M.W. 616.83
Solubility:   chloroform: 10 mg/mL, clear, colorless to light yellow. Alternatively, DMSO: Dissolve in water-miscible organic solvent prior to preparing aqueous solutions. DMSO solutions can be stored dark at -20 °C for at least six months.soluble OR ethanol: Dissolve in water-miscible organic solvent prior to preparing aqueous solutions.soluble
 Storage:  −20°C.

Target: activates protein kinase C in vivo and in vitro

 

 

  

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 Structure    

 

 

 

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Synonym: 12-O-Tetradecanoylphorbol 13-acetate, PMA, TPA, 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate

Molecular Formula: C36H56O8

      

 

        

 

 References      
  - Schmidt, R., and Hecker, E., Autoxidation of phorbol esters under normal storage conditions. Cancer Res. 35, 1375-1377, (1975)      

 

 - Hsu, T.C., et al., Activator protein 1 (AP-1)- and nuclear factor κB (NF-κB)-dependent transcriptional events in carcinogenesis. Free Radic. Biol. Med. 28, 1338-1348, (2000)      

 

 - Daniel, L.W., et al., Phospholipase D, tumor promoters, proliferation and prostaglandins. Biochim. Biophys. Acta 1439, 265-276, (1999)      
  - Liu, W.S., and Heckman, C.A., The sevenfold way of PKC regulation. Cell. Signal. 10, 529-542, (1998)