Actinomycin D

Source: Isolated from Streptomyces parvelus. First time isolated in 1940 by Waksman & Woodruff

Active Product:

Appearance: red to orange powder

Brand name(s): Dactinomycin
Chemical Name: 2-amino-N,N'- bis[(6S,9R,10S,13R,18aS)- 6,13-diisopropyl- 2,5,9-trimethyl- 1,4,7,11,14-pentaoxohexadecahydro- 1H-pyrrolo[2,1-i] [1,4,7,10,13] oxatetraazacyclohexadecin- 10-yl]- 4,6-dimethyl- 3-oxo- 3H-phenoxazine- 1,9-dicarboxamide

Molecular Weight: M.W. 1255.42
Solubility:  Slightly soluble in water (0.5 mg/ml), soluble in DMSO (> 1 mg/ml) and ethanol.  Aliquot and store at -20 °C
Storage:  2-8°C

Target: forms a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis.

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Synonym:  Dactinomycin, Actinomycin C₁, Actinomycin IV

Molecular Formula: C₆₂H₈₆N₁₂O₁₆

- Actinomycin D binding to single-stranded DNA: sequence specificity and hemi-intercalation model from fluorescence and 1H NMR spectroscopy. Wadkins RM, Jares-Erijman EA, Klement R, Rüdiger A, Jovin TM. J Mol Biol. 1996 Sep 13;262(1):53-68.

Partial purification and characterization of DNA-dependent RNA polymerases I and II from cherry salmon (Oncorhynchus masou). Nakayama C, Saneyoshi M, Takiya S, Iwabuchi M. Comp Biochem Physiol B. 1983;74(4):719-23.