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Doxorubicin

Source: Synthetic

Active Product:

Appearance: powder off-white

Brand name(s): Adriamycin PFS, Adriamycin RDF (Farmitalia Carlo Erba S.R.L.), Rubex. Doxil is a liposome-encapsulated form of doxorubicin made by Ben Venue Laboratories for Johnson & Johnson.
 Chemical Name: (8S,10S)-10-(4-amino-5-hydroxy-6-methyl-tetrahydro-2H-pyran-2-yloxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione
Molecular Weight: M.W. 543.5 (C27H29O11N) or 579.98 (C27H29NO11 · HCl)
Solubility:  Soluble in water (10 mg/ml), DMSO and ethanol. Aliquot and store at -20 °C
 Storage: 2-8°C

Target: Topoisomerase II inhibitor. Inhibitor of reverse transcriptase and RNA polymerase;  intercalates in DNA.

 

  

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Comment

 Structure    

 

As an eukaryotic topoisomerase II inhibitors it is thought to act as a poison of the enzyme, stabilising the covalent complex between DNA and enzyme leading to an accumulation of cytotoxic DNA breaks in cells.

 

 

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Synonym:  14-Hydroxydaunorubicin

Molecular Formula: C27H29O11N or C27H29NO11 · HCl

      

 

        

 

 References      

 

 - Seiter K. Toxicity of the topoisomerase II inhibitors. Expert Opin Drug Saf. 2005 Mar;4(2):219-34.

- Rossi CR, Mocellin S, Pilati P, Foletto M, Quintieri L, Palatini P, Lise M. Pharmacokinetics of intraperitoneal cisplatin and doxorubicin.Surg Oncol Clin N Am. 2003 Jul;12(3):781-94.

- Andoh T, Ishida R. Catalytic inhibitors of DNA topoisomerase II. Biochim Biophys Acta. 1998 Oct 1;1400(1-3):155-71.