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Genistein

 

Active Product:

Appearance: powder off-white

Brand name(s):
Chemical Name: 5,7-Dihydroxy-3-(4-hydroxyphenyl)chromen-4-one (also known as 4',5,7-Trihydroxyisoflavone)
Molecular Weight: M.W. 270.24
Solubility:  soluble in DMSO and ethanol, aliquot and store at -20 °C
 Storage: −20 °C

Target: Tyrosine kinases,  Topoisomerase II:  ( IC50 (2.7 mM) for the autophosphorylation of the EGF-R associated tyrosine kinase and  (5 mM) for topoisomerase II). Gensitein inhibits also histidine Kinase,

 

 

  

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Comment

 Structure    

 

A naturally occurring substance found in high amount in soy. Genistein is one of several known isoflavones (e.g. daidzein). Isoflavones (a group of compounds found in and isolated from the soybean) are found in a number of plants, with soybeans and soy products like tofu and textured vegetable protein being the primary food source.

 

 

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Synonym: 5,7-Dihydroxy-3-(4-hydroxyphenyl)chromen-4-one (also known as 4',5,7-Trihydroxyisoflavone)

Molecular Formula: C15H10O5

      

 

        

 

 References      

 

 -Markovits J, Linassier C, Fosse P, et al: Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II. Cancer Res 49: 5111-5117, 1989.

-Motojima K and Goto S: Histidyl phosphorylation and dephosphorylation of P36 in rat liver extract. J Biol Chem 269: 9030-9037, 1994.

-Kim H, Peterson G and Barnes S: Mechanisms of action of the soy isoflavone genistein: emerging role for its effects via transforming growth factor B- signaling pathways. Am J Clin Nutr 68 (suppl): 1418S-1425S, 1998.

-Yakisich JS, Sidén Å, Idoyaga Vargas V, Eneroth P and Cruz M: Early effect of protein kinase modulators on DNA synthesis in rat cerebral cortex. Exp Neurol 159: 164-176, 1999.