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Herbimycin A

 

Active Product:

Appearance: yellow powder

Brand name(s):
Chemical Name: [(2R,3S,5S,6R,7S,8E,10R,11S,12E,14E)-2,5,6,11-tetramethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]
docosa-8,12,14,18,21-pentaen-10-yl] carbamate

Molecular Weight: M.W. 574.66
Solubility:   Soluble in DMSO ( 7.5 mg/mL). This stock solution can be diluted in phosphate buffered saline. The ratio of buffer:DMSO should be greater than 500:1.
 Storage:  −20°C.

Target: protein tyrosine kinase

 

  

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Comment

 Structure    

 

Herbimycin A inhibits protein tyrosine kinase. Herbimycin A is a potent inhibitor of angiogenesis.

 

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Synonym:

Molecular Formula: C30H42N2O9

      

 

        

 

 References      
  - Davis, et al., Herbimycin A and geldanamycin inhibit okadaic acid-induced apoptosis and p38 activation in NRK-52E renal epithelial cells. Toxicol. Appl. Pharmacol. 16, 59-74, (1999)