Hydroxyurea

Chemical Name: : Hydroxyurea
Molecular Weight: M.W. 76.05
Solubility: Soluble H₂O: 50 mg/ml. .Preparation: This product is soluble in H₂O (50 mg/ml). Alternatively, prepare 1 M in H₂O, make aliquots and store at -20 °C.
Active Product:
Appearance: White Powder

Storage: -20 °C

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Comment

Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization (see below) or cell death in S-phase. Widely used to synchronize cells at the G₁/S transition of the cell cycle.

Synonym: hydroxycarbamide

Molecular Formula: NH₂CONHOH

Yarbro, J.W., Mechanism of action of hydroxyurea. Semin. Oncol. 19, 1-10, (1992)