Powered by dominiosweb.org  

                 

 

Rapamycin

Active Product:

Appearance: powder off-white

Brand name(s): Rapamune, Sirolimus
 Chemical Name: (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-
[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]-oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
Molecular Weight: M.W. 914.17
Solubility:  soluble in DMSO. Soluble in ethanol (2 mM). Aliquot and store at -20 °C
 Storage: −20 °C

Target: It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR).

 

 

  

Go to the site   

Advertise here Go to the site Advertise here
 

 

Comment

 Structure    

 

Rapamycin’s name is derived from the native word for Easter Island, Rapi Nui. It is produced by the micro-organism Streptomyces hygroscopius
 

mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway.  mTOR which, among its other functions, inhibits a process called autophagy. Autophagy is the process by which a cell breaks down its own molecules and other components that are no longer needed. Since mTOR functions to inhibit autophagy, by inhibiting mTOR, rapamycin promotes autophagy,

 

 

Go to the site        Advertise here

 

 

  

Synonym: RAPA, AY-22989, NSC-226080,

Molecular Formula: C51H79NO13

      

 

        

 

 References      

 

 - Mita, MM, et al., The molecular target of rapamycin (mTOR) as a therapeutic target against cancer. Cancer Biol. Ther. 2, S169-S177, (2003)