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Sildenafil

 

Active Product:

Appearance:

Brand name(s): Viagra (also known as Vitamin V", "the Blue Pill")
 Chemical Name: 1-[4-ethoxy-3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)phenylsulfonyl]-4-methylpiperazine citrate
Molecular Weight: M.W. 474.6
Solubility:   limited aqueous solubility. Sildenafil citrate can be dissolved in 50 ml of deionized water to a final concentration of 20 μg/ml,
 Storage:  °C

Target: cGMP specific phosphodiesterase type 5 (PDE5), (IC50=0.075 ± 0.004 μM)

 

 

  

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Comment

 Structure    

 

Sildenafil is a potent and selective inhibitor of phosphodiesterase type 5 (PDE5), the predominant isozyme responsible for the metabolism of cGMP in the corpus cavernosum of the penis. The molecular structure of sildenafil is similar to that of cGMP and acts as a competitive binding agent of PDE5 in the corpus cavernosum, resulting in more cGMP and better erections. Sildenafil is a potent and selective inhibitor of phosphodiesterase type 5 (PDE5), the predominant isozyme responsible for the metabolism of cGMP in the corpus cavernosum of the penis.

 

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Synonym: 1-[4-ethoxy-3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)phenylsulfonyl]-4-methylpiperazine citrate

Molecular Formula: C22H30N6O4S 

      

 

        

 

 References      

 

Dell'Agli M, Galli GV, Dal Cero E, Belluti F, Matera R, Zironi E, Pagliuca G, Bosisio E. Potent inhibition of human phosphodiesterase-5 by icariin derivatives. J Nat Prod. 2008 Sep;71(9):1513-7.

Wang Y, Chow MS, Zuo Z. Mechanistic analysis of pH-dependent solubility and trans-membrane permeability of amphoteric compounds: application to sildenafil. Int J Pharm. 2008 Mar 20;352(1-2):217-24.