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Sodium Butyrate

 

Active Product:

Appearance: white crystalline solid with an unpleasant smell

Brand name(s):
Chemical Name:
Molecular Weight: M.W. 110.09
Solubility:  soluble in water (500 mM), aliquot and store at -20 °C
 Storage: −20 °C

Target: Sodium butyrate (0.25 - 5 mM) inhibits histone deacetylase (HDAC) in cultured cells. Inhibits most HDAC except class III HDAC and class II HDAC6 and -10.

 

 

  

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Comment

 Structure    

 

Decreases Ca2+ release from intracellular stores.

 

 

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Synonym: Butyric acid sodium salt, sodium butanoate

Molecular Formula: CH3CH2CH2COONa

      

 

        

 

 References      

 

- Monneret C. Histone deacetylase inhibitors. Eur J Med Chem. 2005 Jan;40(1):1-13.

- Davie JR.Inhibition of histone deacetylase activity by butyrate.J Nutr. 2003 Jul;133(7 Suppl):2485S-2493S.

- Candido, E. P. M., Reeves, R. & Davie, J. R. (1978) Sodium butyrate inhibits histone deacetylation in cultured cells. Cell 14: 105–113.