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Staurospoirne

 

Active Product:

Appearance: powder light yellow

Brand name(s):
Chemical Name: (9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
Molecular Weight: M.W. 466.53
Solubility: Insoluble in water. Soluble in DMSO, methanol and ethanol. Aliquot and store at -20 °C
 Storage: 2-8°C

Target: Serine and threonine kinases through the prevention of ATP binding to the kinase.

  

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Comment

 Structure    

 

Staurosporine is a natural product originally isolated by Omura et al in 1977 from bacterium Streptomyces staurosporeus

 

 

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Synonym: Antibiotic AM-2282, STS

Molecular Formula: C28H26N4O3

      

 

        

 

 References      

 

- Omura S, Iwai Y, Hirano A, Nakagawa A, Awaya J, Tsuchiya H, Takahashi Y, Masuma R (1977). "A new alkaloid AM-2282 of Streptomyces origin taxonomy, fermentation, isolation and preliminary characterization". J. Antibiot. 30 (4): 275–282. 

- Tamaoki T. Use and specificity of staurosporine, UCN-01, and calphostin C as protein kinase inhibitors. Methods Enzymol. 1991;201:340-7.

- Yakisich JS, Sidén Å, Idoyaga Vargas V, Eneroth P and Cruz M: Early effect of protein kinase modulators on DNA synthesis in rat cerebral cortex. Exp Neurol 159: 164-176, 1999.