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Topotecan

 

Source: Semi-synthetic water soluble derivative of Camptothecin

Active Product:

Appearance:

Brand name(s): Hycamtin
 Chemical Name: (S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione monohydrochloride

Molecular Weight: M.W. 421.5
Solubility:    Soluble in water (1 mg/ml). Aliquot and store at -20 °C
 Storage: −20 °C. 

Target: topoisomerase I inhibitor.  Approximately 0.5 µM topotecan induces 50% topo I DNA cleavage (Holden et al, 1999)

  

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Comment

 Structure    

 

 Topotecan is the first topoisomerase inhibitor for oral use.

 

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Synonym:  

Molecular Formula: C23H23N3O5

      

 

        

 

 References      

 

 - Lerchen HG. Camptothecin antitumor agents. IDrugs. 1999 Sep;2(9):896-906.

- Holden JA, Wall ME, Wani MC, Manikumar G. Human DNA topoisomerase I: quantitative analysis of the effects of camptothecin analogs and the benzophenanthridine alkaloids nitidine and 6-ethoxydihydronitidine on DNA topoisomerase I-induced DNA strand breakage. Arch Biochem Biophys. 1999 Oct 1;370(1):66-76.