Zoledronic Acid

Zoledronic Acid

Active Product:

Appearance: White or almost crystalline powder

Brand name(s): Zometa, Zomera, Aclasta and Reclast
Chemical Name: (1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl) phosphonic acid
Molecular Weight: M.W. 272.09
Solubility: highly soluble in 0.1 N sodium hydroxide solution, sparingly soluble in water and 0.1 N hydrochloric acid, and practically insoluble in organic solvents . Preparation:
Storage: °C

Target: Farnesyl pyrophosphate synthetase

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Comment	Structure
Inhibits osteoclastic bone resorption. It has a high affinity for hydroxyapatite, resulting in its rapid and preferential accumulation in bone tissue. It is released from bone surfaces during bone resorption, and internalized by osteoclasts, where it mediatesits antiresorptive activity by inhibiting the mevalonate pathway (Lyseng-Williamson, 2008).

	Synonym: Zoledronate Molecular Formula: C₅H₁₀N₂O₇P₂	Go to the site	Advertise here

Studies	References
- Zoledronic acid 4 mg administered as a 15-minute infusion every 3-4 weeks is effective and well tolerated in the treatment of patients with breast cancer metastatic to bone. It is effective	Lyseng-Williamson 2008


References Deeks ED, Perry CM. Zoledronic acid: a review of its use in the treatment of osteoporosis. Drugs Aging. 2008;25(11):963-86 Lyseng-Williamson KA. Zoledronic Acid: a review of its use in breast cancer. Drugs. 2008;68(18):2661-82.